Low Prices
The low prices provided by mass purchasing are derived not from lower expense, but from the power to force others to charge less. This practice shifts burden, it does not lighten it. More importantly, it shifts burden away from those with plentiful resources who can use their extra energy to create such systems, and further onto those with scarce resources. This is a self serving mechanism that promotes the deepening of economic disparity in the world, and also resentment towards the ones benefiting.
Prohibition
Substance prohibition is a costly stance that victimizes citizens who have performed crimes with no victim. This only serves to create more victims in the world. Further, it causes substance users who are already in a difficult position to fear the authorities that could help them and forces the industry that provides illegal drugs to be adversarial towards the government. Instead of controlling and taxing substances, the government chooses to spend money on prosecution and imprisonment, while lack of regulation makes the substances more dangerous to users. Because substance production and distribution are outside of the law, people who partake in these practices are more likely to use other forms of crime which actually do create victims such as violence and theft because they know that they are in trouble if they are ever forced to interact with legal authorities. Indeed, this fear puts greater than normal stress on people who are doubly likely to have impaired judgement, based not only on their chemical use but also on the preexisting conditions that led them to seek out illegal drugs in the first place.