by Michael W. Beug Email: beugm@evergreen.edu
The Evergreen State College, Olympia WA
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Slide 9.
Conocybe filaris, also known as Pholiotina filaris, is another species that can contain lethal levels of the amanitins and also grows mixed in with similar-sized Psilocybes. Like all of the mushrooms shown so far, the critical feature is that the onset of symptoms will be delayed for 6-24 hours and then after a period of intense gastrointestinal distress the patient will appear to recover before having a very serious, potentially fatal, reappearance of symptoms coupled with elevated liver enzymes. The amatoxins inhibit RNA polymerase, which transcribes m-RNA. They affect the gastrointestinal epithelium, centrilobular hepatocytes and nephrocytes in the proximal convoluted tubes. Kidney and liver failure follows with bleeding and neurologic dysfunction. There are a number of important serum tests available to doctors to assist in tracking treatments.
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