International Grants involving Phage and the Eliava Institute:
-Information on the International Science
and Technology Centers (ISTC) program
-Science and Technology
Centers in the Ukraine (STCU) program
-Civilian Research and Defense Fund (CRDF)
program
These programs were set up to help scientists once supported by the
Soviet military make a productive transition to the civilian sector; they
are associated with the State Department and also involve Europe and Japan.
They have become very supportive of phage work - 2 State Department representatives
actually came to the last Evergreen Phage meeting to encourage involvement
in their programs.
Projects under way:
Molecular Mechanisms of Bacteriophage Evolution and Host-to-Virus Transcription
Transition During Bacteriophage Infection in Pathogenic Bacteria. PI
- Tato Gabisonia; US Dept. of Health and Human Services, Rockville; US Partner:
Konstantin Severinov, Rutgers; BTEP ISTC Grant G587
Analysis of Phage Specific Potentially Lethal Genes and Investigation
of Antibacterial Activity of" Killer" Proteins. PIs - Mzia
Kutateladze & Rezo Adamia. US partners: Jan Drake (National Institute
of Environmental Health Sciences), Elizabeth Kutter, Charles Stewart;
BTEP ISTC Grant G595
A new strategy for control of potato bacterial diseases based on application
of specific phages. PI, Marina Tediashvili; partner: 3M; CRDF Grant
N 527
Bacteriophage - a new approach for combating of the nosocomial respiratory
infection caused by Ps. aeruginosa. PI - Nino Chanishvili, Co-ordinator
- Paul Barrow, UK, INTAS-Georgia (joint funding from EC and Georgia) (completed)
An epidemiological study of outbreaks of B. anthraxis in Georgia.
PI- Sergo Rigvava, Co-ordinator Richard Sharp, CAMR, UK; INTAS Open Call
Regional Experimental Center for Applied and Microbiology Research
(RECAMBR). PI- Nino Chanishvili -- CRDF - Regional Experimental Support
Centers Program
Student Project 2001: Nino Chanishvili CRDF G 589
*Approved; still negotiating final research plan: [This step often
takes over a year.]
* Bacteriophages for the Treatment of Infectious Diseases Caused by
Antibiotic-Resistant Bacterial Strains of Staphylococcus Aureus and Pseudomonas
Aeruginosa. PI: Nana Balarjishvili. NATO partners: Henry Krisch (Toulouse);
Elizabeth Kutter (Evergreen) ISTC Grant G510
* Sustained/Controlled-Release Drug Devices Containing Bacteriophages
Based on New Biodegradable Poly (ester amide)s. Amiran Meipariani
and Zemphira Alavidze [Supporting institute: Georgian Technical University
/ Research Center for Medical Polymers and Biomaterials, Tbilisi, Georgia
- Ramaz Katsarava] -- ISTC Grant G589
* Monitoring and preventing the after-effects of natural hazards and
water-borne epidemics through application of phage-based techniques.
PI: Nino Chanishvili. [Supporting institutes: National Center for Diseases
Control, Tbilisi, Georgia; Geophysics Institute, Tbilisi, Georgia. US
collaborator: University of North Carolina/Carolina Environmental Program,
Partner: US Department of Health & Human Services, Rockville, MD,
BTEP ISTC Grant G608
**Waiting for granting board decisions:
** Different Medicinal Forms of Bacteriophages for Treatment and Prevention
of Bacterial Infections Induced by the Genera of Staphylococcus and Streptococcus
- Inga Georgadze; Collaborator: University of Maryland / School of Medicine
/ Department of Epidemiology and Preventive Medicine, Baltimore -- ISTC
G824
** Prolonged Acting, High Effective, Antimastitis Preparation Composed
Of Bacteriophages, Hyaluronidase And Biodegradable Polymer. PI: Tato
Gabisonia; [Supporting institute: Georgian Technical University / Research
Center for Medical Polymers and Biomaterials, Tbilisi, Georgia - Ramaz
Katsarava]; US collaborator: Elizabeth Kutter -- STCU
** Study of interaction between antibiotics and bacteriophages in vitro
taking into account the resistance of strains isolated from patients during
the treatment of suppurative infections. PI: Zemphira Alavidze. [Collaboration:
Dr. Guram Gvasalia, Regional Hospital] -- STCU
** Medicinal-Prophylactic Phage Preparation Against Bacterial Complications
Induced by Proteus and Pseudomonas, in Extreme Conditions. PIs: Liana
Gachechiladze and Inga Georgadze; US collaborator: Elizabeth Kutter -
CRDF
Scientists from the Eliava Institute are also collaborators on other
international grants where the PIs are from other Georgian institutions;
CR: Eliava Institute lead collaborator
Bacteriophages Containing Drug Sustained/Controlled Release Type Polymeric
Composites - New Effective Preparations for the Treatment of Infected
Wounds and Cavities. Georgian Technical University / Research Center
for Medical Polymers and Biomaterials, Tbilisi, Georgia - Ramaz Katsarava.
Eliava Institute collaborators: Zemphira Alavidze and Amiran Meipariani.
US collaborator: Glenn Morris, University of Maryland. ISTC Grant G446
[The Katsarava group has also been awarded a CRDF grant for development
of a Regional Research Center for work with biopolymers and an
additional ISTC grant is in the work plan-negotiation stages; these are
clearly both also relevant to the goal of commercially making Phage Bioderm,
which incorporates phages obtained from the Eliava Institute.]
The Biological Dispersion Phenomenon and the Energetic of Microplankton:
A Search for the Regularities and the Relationship to Environmental Fluctuations.
CR Marina Tediashvili, Co-ordinator Professor Richard Kemp University
of Wales, UK, INTAS Grant N 1390
Prevention of food spoilage by suppression of phenoloxidase perioxidase
and growth of pathogenic micro-flora by use of natural inhibitors of plant
origin. CR Marina Tediashvili, Co-ordinator , Jose Neptuno Rodrigues
Lopes, University of Mursia, Spain- INTAS FOOD-2000
Evaluation of coastal pollution status and bio-indicators for the
Black Sea (BIOBS). CR, Marina Tediashvili, Co-ordinator James Wilson,
Center for the Environment Trinity College, Dublin, Ireland INTAS-Polluted
Environments
Bacteriophage against a number of medication resistant conditionally
- pathogenic bacteria as an alternative to antibiotics. Biochimpharm
Joint Stock Company (Golidjashvili Aleksandr Otarovich); Eliava Co-PI:Liana
Gachechiladze. NATO collaborators: Humboldt University School of Medicine
Charite, the Institute of Virology, Berlin; Elizabeth Kutter, Evergreen
State College *ISTC Grant G534
Tuberculosis Bacteriophage: Development of Obtainment and Application
Methods. Sergey Vashakidze Institute of Tuberculosis and Pulmonology,
Tbilisi, Georgia; US collaborators: Merlin Technologies, Inc., Boston,
MA; Public Health Research Institute, New York ** ISTC Grant G591
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For more information contact Dr. Elizabeth Kutter at phagebiotics@attbi.com.
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